Migraine Cocktail

Welcome to our dedicated page on the Migraine Cocktail, a preventive strategy we recommend for patients experiencing frequent migraines. This regimen combines several vitamins and supplements known for their potential to reduce the frequency, severity, and duration of migraine attacks.

Components of the Migraine Cocktail

The Migraine Cocktail consists of:

  1. Vitamin B2 (Riboflavin) - 400mg once per day
  2. Helps in energy production within cells, potentially reducing migraine frequency.
  3. Magnesium - 500mg once at night
  4. Involved in nerve transmission and muscle contraction. Magnesium deficiency has been linked to increased migraine attacks.
  5. Butterbur - 150mg once per day
  6. A herbal supplement shown to reduce migraine frequency. Note: Choose PA-free butterbur to avoid liver toxicity risks.
  7. Coenzyme Q10 (CoQ10) - 100mg three times a day
  8. Plays a role in energy production. Studies suggest it may decrease migraine frequency.
  9. Ginkgo Biloba - once per day (dose varies)
  10. Known for its antioxidant properties and potential to improve circulation, which might help in managing migraines.

How Does It Work?

The Migraine Cocktail works by targeting different aspects of migraine pathology. From improving mitochondrial function and reducing oxidative stress to stabilizing blood vessel and nerve function, each component has a role in mitigating the complex mechanisms involved in migraine attacks.

Safety and Side Effects

While these supplements are generally safe, they can interact with other medications and have potential side effects. It's crucial to discuss with your healthcare provider before starting this regimen, especially if you are pregnant, nursing, or have underlying health conditions.

  • Vitamin B2: Generally well-tolerated, though may cause urine to turn bright yellow.
  • Magnesium: Can cause diarrhea or gastrointestinal upset in some individuals.
  • Butterbur: Must be PA-free. The liver toxicity risk is associated with preparations containing pyrrolizidine alkaloids (PAs).
  • CoQ10: Rarely, it can cause stomach upset, loss of appetite, nausea, and diarrhea.
  • Ginkgo Biloba: Possible mild side effects include stomach upset, headache, or allergic skin reactions.


The Migraine Cocktail represents a holistic approach to migraine management, focusing on prevention through nutritional and herbal supplements. As with any treatment regimen, it's essential to consult with your healthcare provider to ensure this approach is suitable for you, considering your medical history and current medications.